Acetic Acid → HCID 22481953, compound

Participants

Reaction Steps

To an ice-cold suspension of 2-benzyloxy-N-ureidocarbonyl-propionamide (9.4 mmol, 2.5 g) in water (15 mL) was added KOH (28 mmol, 1.6 g) in water (10 mL). The reaction temperature was slowly raised to room temperature, and the reaction was allowed to stir for 1 h. Sufficient acetic acid was added to adjust the pH of the reaction to 5, and the resulting cloudy solution was extracted with chloroform (3×20 mL). The chloroform layer was collected, dried, filtered and the filtrate was concentrated to obtain a residue, which was triturated with isopropyl ether to obtain 6-(1-benzyloxy-ethyl)-1H-[1,3,5]triazine-2,4-dione (74%, 1.72 g); NMR 1.4 (d, 3H), 4.2 (t, 1H), 4.6 (dd, 2H), 7.4 (m, 5H), 11.2 (s, 1H), 12.1 (s, 1H).

Provenance & Evidence