HCID 22482097, compound → HCID 22482102, compound

HRID 2181634Notes

Reaction equation

HRID 2181634 reaction equation
[ClH:1].Cl.[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([C:29]2[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=2)[CH2:12][C:13]([N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[O:27][CH3:28])[CH2:17][CH2:16]2)=O)=[CH:7][CH:6]=1.[N+](C1C=CC(C(C2C=CC([N+]([O-])=O)=CC=2)CC(N2CCN(C3C=CC=CC=3OC)CC2)=O)=CC=1)([O-])=O>>[ClH:1].[ClH:1].[CH3:36][O:35][C:32]1[CH:31]=[CH:30][C:29]([CH:11]([C:8]2[CH:9]=[CH:10][C:5]([O:4][CH3:3])=[CH:6][CH:7]=2)[CH2:12][CH2:13][N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[O:27][CH3:28])[CH2:17][CH2:16]2)=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 22482097HCID 22482097, compoundHCID 22482109HCID 22482109, compound

Product 1

HCID 22482102HCID 22482102, compound

Procedure

This product was obtained in accordance with the procedure described above, (in Example 3b), with the sole exception that Compound 4A was employed here in place of Compound 3A. In addition, extraction was carried out here with ethyl acetate rather than chloroform. The obtained residue was dissolved in diethyl ether; then, after treatment with charcoal, the resultant solution was acidified with excess hydrochloric acid (3 N solution, in diethyl ether). After 3 h, the precipitate was recovered by filtration; the title product melted at 163-171° C.

Workup

  1. customThis product was obtained in accordance with the procedure
  2. extractionIn addition, extraction
  3. dissolutionThe obtained residue was dissolved in diethyl ether
  4. filtrationthe precipitate was recovered by filtration

Sources & evidence

ORD record
ord-dd5bf484b3b7406293205ce38234102f
Source dataset
uspto-grants-2005_05
Patent number
US06894052B1

Reaction notes

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