2,2'-Dipyridylamine → 3,3-Bis-(2-pyridyl)propionaldehyde dimethyl acetal

Participants

Reaction Steps

This product was prepared as described above, (in Example 5), with the exception that bis-(2-pyridyl)amine was replaced by bis-(2-pyridyl)methane (prepared as described in Heterocycles 1995, 40, 757-776) and substituting 1-(2-chloroethyl)-4-(2-methoxyphenyl)piperazine with 2-bromoacetaldehyde dimethyl acetal. After 12.5 h at reflux the reaction mixture was worked-up as described above. The crude residue was purified by flash chromatography (ethyl acetate-petroleum ether-2.2 N methanolic ammonia 6:4:0.6) affording the title product (77%).

Provenance & Evidence