3,3-Bis-(2-pyridyl)propionaldehyde dimethyl acetal → 3,3-Bis-(2-pyridyl)propionaldehyde

Participants

Reaction Conditions

Reaction Steps

A solution of 1.86 g of Compound 16A and 0.08 g of 1,4-dihydroquinone in 36 mL of 2 N HCl was stirred at 80° C. for 15 min, cooled to 0° C., diluted with 50 mL of dichloromethane and neutralized with 20% aq. sodium carbonate (pH=7-8). The organic layer was dried on sodium sulphate and evaporated to dryness affording 1.15 g of crude title compound as a grey glassy solid, which was used in the next step without any further purification.

Provenance & Evidence