(R)-(+)-3-Aminoquinuclidine Dihydrochloride → HCID 69794740, compound

Participants

Reaction Steps

2-(Diethoxymethyl)-1-benzofuran-6-carboxylic acid (264 mg, 1.0 mmol) is coupled with (R)-3-aminoquinuclidine dihydrochloride (219 mg, 1.1 mmol) and salt made according to Method A with non-critical changes to afford 286 mg (70%) of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-(diethoxymethyl)-1-benzofuran-6-carboxamide hydrochloride as a white solid. HRMS (FAB) calcd for C21H28N2O4+H: 373.2127, found 373.2121 (M+H)+.

Provenance & Evidence