Water → 3-Prop-1-ynyl-1-benzofuran-5-carboxylic acid

関与物質

反応手順

Methyl 3-prop-1-ynyl-1-benzofuran-5-carboxylate (388 mg, 1.81 mmol) is dissolved in 10 ml MeOH. The solution is treated with 2N NaOH (2.3 ml, 4.6 mmol) followed by 2 ml H2O and the reaction is stirred overnight at RT. The reaction is concentrated to dryness, the residue is dissolved in 9 ml H2O, and the pH is adjusted to 3 with 10% aqueous HCl. The precipitate is collected, washed with H2O, and is dried to afford 356 mg (98%) of 3-prop-1-ynyl-1-benzofuran-5-carboxylic acid as an off-white solid. HRMS (EI) calcd for C12H8O3: 200.0473, found 200.0476 (M+).

情報源と証拠