HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 218169Generated: October 25, 2026
Bromocycloheptane → methyl 3-(1-cycloheptyl-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate
https://huagongshe.com/reaction/218169
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromocycloheptane | HCID 16992 | — |
| Reactant | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Reactant | methyl 3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate | HCID 59251051 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | methyl 3-(1-cycloheptyl-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate | HCID 68702551 | 60% |
Reaction Steps
Methyl 3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate (500 mg, 1.62 mmol, prepared in Synthetic Intermediate III(c)) was dissolved in 5 mL DMSO and NaHMDS (2.4 mL, 2.4 mmol, 1.0 M in THF) was added followed by bromocycloheptane (446 uL, 3.25 mmol). The reaction was heated overnight at 85° C. The reaction was quenched with TFA and purified by HPLC to give methyl 3-(1-cycloheptyl-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate (393 mg, 60%). (M+H)+=405.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08198311B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-60fecc13f5284888bf25953c32ff45cc |
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| Source note | uspto-grants-2012_06 |
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