HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-(1-cycloheptyl-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | methyl 3-(1-cycloheptyl-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate | HCID 68702551 | — |
| Solvent | Dimethyl sulfoxide methanol | HCID 22036561 | — |
| Product | 3-(1-cycloheptyl-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid | HCID 68703961 | 103.7% |
Reaction Steps
Methyl 3-(1-cycloheptyl-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate (393 mg, 0.97 mmol) was hydrolyzed by heating with 10 equiv NaOH in 3:1 DMSO/MeOH (10 mL). Purified by HPLC to give 393 mg of 3-(1-cycloheptyl-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid. (M+H)+=391.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198311B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-b0daa99bded741fd9ce43de3ea9983e2 |
| Source note | uspto-grants-2012_06 |