Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 3-Dichloromethylthio-7-fluoro-1-methyl-4-quinolone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 3-Chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone | HCID 10468547 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 3-Dichloromethylthio-7-fluoro-1-methyl-4-quinolone | HCID 11323779 | — |
반응 단계
To an efficiently stirred and gently cooled 4.2 ml mixture of thionyl chloride (“SOCl2”) and 1.05 ml of pyridine (“Py”) at −3° C. was added 1.015 g (3.708 mmol) of 3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone (monochloroflosequinan) (Compound 1 of FIG. 1). This addition was made in multiple alloquots over a period of approximately 1 min. During this addition, cooling was applied to keep the temperature in the range 0-5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06894166B2 |
| 출처 데이터셋 | uspto-grants-2005_05 |
| ORD ID | ord-45a8f65e14a94100ac1826e7d5c685a6 |
| 출처 메모 | uspto-grants-2005_05 |