Dichloromethane → HCID 10473142, compound

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Reaction Steps

The title compound was prepared from (R)-5-[(4-methoxyphenyl)sulfonyl]-6-methyl-5,6-dihydrophenanthridine (0.38 g, 1.04 mmol), cyclohexene (0.27 mL, 2.61 mmol), and 1.0 M boron tribromide in dichloromethane (6.27 mL, 6.27 mmol) according to the procedure and in the same manner as described in Example 1, step b. The crude product was purified by flash column chromatography on silica gel, eluting with dichloromethane, to yield 4-{[(R)-6-methylphenanthridin-5(6H)-yl]sulfonyl}phenol* (0.26 g, 0.74 mmol, 71%) as a white, solid, single enantiomer, m.p. 181-183° C.;

Provenance & Evidence