Dichloromethane → HCID 10408278, compound

Participants

Reaction Steps

The title compound was prepared from (S)-6-tert-butyl-5-[(4-methoxyphenyl)sulfonyl]-5,6-dihydrophenanthridine (1.35 g, 3.31 mmol), cyclohexene (6.16 g, 75 mmol), and 1.0 M boron tribromide in dichloromethane (20 mL, 20 mmol) according to the procedure and in the same manner as described in Example 12, step b; and yielded, after chromatographic purification and crystallization from a mixture of diethyl ether-hexane, 4-{[(S)-6-tert-butylphenanthridin-5(6H)-yl]sulfonyl}phenol* (0.975 g, 2.48 mmol, 75%) as a homogeneous, colorless, crystalline (prisms), single enantiomer*, m.p. 187-189° C.;

Provenance & Evidence