Sodium Hydroxide → 4-{[(S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]sulfonyl}phenol

Participants

Reaction Steps

The title compound was prepared from ethyl 4-{[(S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]sulfonyl}phenyl carbonate (0.05 g, 0.11 mmol), 2.5 N aqueous sodium hydroxide (2 mL, 5 mmol), and methanol (2 mL), according to the procedure and in the same manner as described in Example 32, Method A, Step e to yield 4-{[(S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]sulfonyl}phenol as a solid (0.04 g, 100%), m.p. 193° C.;

Provenance & Evidence