Sodium Hydroxide → HCID 9999147, compound

HRID 2181821Notes

Reaction equation

HRID 2181821 reaction equation
C(=O)([O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([N:15]2[C@H:28]([CH3:29])[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([F:30])[CH:26]=3)[C:21]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]2=3)(=[O:14])=[O:13])=[CH:8][CH:7]=1)OCC.[OH-].[Na+]>CO>[F:30][C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[C:21]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:15]([S:12]([C:9]1[CH:8]=[CH:7][C:6]([OH:5])=[CH:11][CH:10]=1)(=[O:14])=[O:13])[C@@H:28]2[CH3:29]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69354615HCID 69354615, compound

Product 1

HCID 9999147HCID 9999147, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared from ethyl 4-{[(R)-8-fluoro-6-methylphenanthridin-5(6H)-yl]sulfonyl}phenyl carbonate (0.05 g, 0.11 mmol), a 2.5 N aqueous sodium hydroxide solution (2 mL, 5 mmol), and methanol (2 mL), according to the procedure and in the same manner as described in Example 32, Method A, Step e to yield 4-{[(R)-8-fluoro-6-methylphenanthridin-5(6H)-yl]sulfonyl}phenol* as a solid (0.04 g, 100%), m.p. 193° C.;

Sources & evidence

ORD record
ord-efe557855f4d4de697014ffead47f771
Source dataset
uspto-grants-2005_05
Patent number
US06894061B2

Reaction notes

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