Dichloromethane → HCID 9999147, compound

Participants

Reaction Steps

The title compound was prepared from (R)-8-fluoro-5-[(4-methoxyphenyl)sulfonyl]-6-methyl-5,6-dihydrophenanthridine (0.74 g, 1.93 mmol), cyclohexene (7.0 mL, 70.0 mmol), and 1 M boron tribromide in dichloromethane (23 mL, 23 mmol) according to the procedure and in the same manner as described in Example 32, Method B, Step b. The crude product was purified by flash column chromatography on silica gel, eluting with a mixture of ethyl acetate-hexane (1:9 to 1:4 gradient), followed by trituration from hot hexane to yield 4-{[(R)-8-fluoro-6-methylphenanthridin-5(6H)-yl]sulfonyl}phenol* as a solid (0.52 g, 73%), m.p. 193° C.

Provenance & Evidence