HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 22482328, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | 4-Bromo-2-iodoaniline | HCID 823934 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 22482328 | HCID 22482328 | — |
Reaction Steps
5-Bromo-4′-fluoro-1,1′-biphenyl-2-ylamine was prepared from the above intermediate, 4-bromo-2-iodoaniline (12.6 g, 42.2 mmol), 4-fluorophenylboronic acid (5.9 g, 42 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (II) complex with dichloromethane (0.69 g, 0.84 mmol), and a 5 N aqueous sodium hydroxide solution (85 mL, 425 mmol) according to the procedure and in the same manner as described in Example 32, Method A, Step a.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06894061B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-e163e59d33f143a5aa0084b0542b2658 |
| Source note | uspto-grants-2005_05 |