Diethyl Ether → 5-[(3-Fluoro-4-methoxyphenyl)sulfonyl]-6-methyl-5,6-dihydrophenanthridine

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Reaction Steps

The title compound was prepared from phenanthridine (7.17 g, 40 mmol), 1.4 M methyllithium in diethyl ether (29 mL, 40.6 mmol), and 3-fluoro-4-methoxybenzenesulfonyl chloride (8.99 g, 40 mmol) according to the procedure and in the same manner as described in Example 1, step a. The crude product was purified by re-crystallization from a mixture of ethyl acetate-cyclohexane to yield 5-[(3-fluoro-4-methoxyphenyl)sulfonyl]-6-methyl-5,6-dihydrophenanthridine (6.79 g, 17.7 mmol, 44%) as an off-white solid;

Provenance & Evidence