Chlorosulfonic acid → 4-Methoxy-3,5-dimethylbenzene-1-sulfonyl chloride

HRID 2181873Notes

Reaction equation

[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][C:4]=1[CH3:10].[Cl:11][S:12](O)(=[O:14])=[O:13]>>[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][C:6]([S:12]([Cl:11])(=[O:14])=[O:13])=[CH:5][C:4]=1[CH3:10]

Participants

Reactant 2

HCID 24638Chlorosulfonic acid

HCID 660882,6-Dimethylanisole

Product 1

HCID 224823214-Methoxy-3,5-dimethylbenzene-1-sulfonyl chlorideYield 63%

Procedure

The title compound was prepared from 2-methoxy-1,3-dimethylbenzene (6.81 g, 50 mmol) and chlorosulfonic acid (6.65 mL, 100 mmol), according to the procedure and in the same manner as described in Example 58, step b to yield 4-methoxy-3,5-dimethylbenzenesulfonyl chloride (7.43 g, 31.3 mmol, 63%) as a white solid;

Sources & evidence

ORD record: ord-cf4a4effa2c34546bdcad9c4f9693126
Source dataset: uspto-grants-2005_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06894061B2

Reaction notes

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