Pyridine → N-(4'-chloro-1,1'-biphenyl-2-yl)acetamide

Participants

Reaction Steps

The title compound was prepared from 4′-chloro-1,1′-biphenyl-2-amine (3.5 g, 17.19 mmol), acetic anhydride (1.79 mL, 18.9 mmol), pyridine (3.2 mL, 39.5 mmol), and 4-(N,N-dimethylamino)pyridine (0.06 g, 0.52 mmol) according to the procedure and in the same manner as described in Example 60, step b. The crude product was purified by re-crystallization from a mixture of ethyl acetate-hexane to yield N-(4′-chloro-1,1′-biphenyl-2-yl)acetamide (2.16 g, 8.78 mmol, 51%) as a white solid;

Provenance & Evidence