反应详情

The title compound was prepared from 3-methoxybenzenesulfonyl chloride (341 mg, 1.7 mmol), 1-(-2′,4′-difluoro-biphenyl-2-yl)ethylamine (350 mg, 1.5 mmol), and triethylamine (418 μL, 3 mmol) according to the procedure and in the same manner as described in Example 105, step c. The solid was purified by preparative liquid chromatography on a Biotage® 40 Mi column of prepacked silica gel (90 g), eluting with a gradient of 30%-50% methyl tert-butyl ether in hexane (35 min), and the product (473 mg, 78%) isolated as a white solid, m.p. 127.5-129° C.;

1. customThe solid was purified by preparative liquid chromatography on a Biotage® 40 Mi column of prepacked silica gel (90 g)
2. washeluting with a gradient of 30%-50% methyl tert-butyl ether in hexane (35 min)