反应详情

The title compound was prepared from 3-methoxybenzenesulfonyl chloride (326 mg, 1.6 mmol), 1-(-2′,5′-difluoro-biphenyl-2-yl)ethylamine (350 mg, 1.5 mmol), and triethylamine (418 μL, 3 mmol) according to the procedure and in the same manner as described in Example 112, step c. The product was purified by preparative liquid chromatography on a Biotage® 40 Mi column of prepacked silica gel (90 g), eluting with a gradient of 30%-50% methyl tert-butyl ether in hexane (35 min), to afford the desired compound (570 mg, 94%) as a clear glass;

1. customThe product was purified by preparative liquid chromatography on a Biotage® 40 Mi column of prepacked silica gel (90 g)
2. washeluting with a gradient of 30%-50% methyl tert-butyl ether in hexane (35 min)