2-Bromo-5-fluorophenol → 1-Bromo-4-fluoro-2-[(prop-2-yn-1-yl)oxy]benzene

HRID 2182036Notes

Reaction equation

HRID 2182036 reaction equation
F[C:2]1([O:9][C:10]#[C:11][CH3:12])[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][CH2:3]1.[Br:13]C1C=CC(F)=CC=1O.BrC1C=C(F)C=CC=1OCC#C>>[Br:13][C:3]1[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=1[O:9][CH2:10][C:11]#[CH:12]

Participants

4

Reactant 3

HCID 27246002-Bromo-5-fluorophenolHCID 224828682-Bromo-4-fluoro-1-prop-2-ynyloxybenzeneHCID 670477642,4-Difluoro-2-propynyloxybenzene

Product 1

HCID 224828471-Bromo-4-fluoro-2-[(prop-2-yn-1-yl)oxy]benzeneYield 87%

Procedure

This compound was prepared analogously to 2,4-difluoro-2-prop-ynyloxy-benzene but using 2-bromo-5-fluorphenol (15 g, 78 mmol) to give 1-bromo-4-fluoro-2-prop-2-ynyloxy-benzene 15.6 g (87%) 29f) 2-Bromo-4-fluoro-1-prop-2-ynyloxy-benzene

Sources & evidence

ORD record
ord-e59c55abcb6947248fa994843885ee83
Source dataset
uspto-grants-2005_05
Patent number
US06894177B2

Reaction notes

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