4-Methyl-2,3,5,6-tetrafluorobenzyl alcohol → kappa-Tefluthrin

HRID 2182049Notes

Reaction equation

HRID 2182049 reaction equation
[CH3:1][C:2]1[C:9]([F:10])=[C:8]([F:11])[C:5]([CH2:6][OH:7])=[C:4]([F:12])[C:3]=1[F:13].[Cl:14]/[C:15](=[CH:20]\[C@@H:21]1[C@H:23]([C:24](Cl)=[O:25])[C:22]1([CH3:28])[CH3:27])/[C:16]([F:19])([F:18])[F:17]>>[CH3:1][C:2]1[C:9]([F:10])=[C:8]([F:11])[C:5]([CH2:6][O:7][C:24]([C@H:23]2[C:22]([CH3:28])([CH3:27])[C@H:21]2/[CH:20]=[C:15](\[Cl:14])/[C:16]([F:19])([F:18])[F:17])=[O:25])=[C:4]([F:12])[C:3]=1[F:13]

Participants

3

Reactant 2

HCID 27342094-Methyl-2,3,5,6-tetrafluorobenzyl alcoholHCID 11334477(1RS)-cis-3-(Z-2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarbonyl chloride

Product 1

HCID 11350631kappa-Tefluthrin

Procedure

In a further aspect of the invention the 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol is reacted with cis-Z 3-(2-chloro-1,1,1-trifluoro-2-propenyl)-2,2-dimethylcyclopropane carbonyl chloride to give tefluthrin.

Sources & evidence

ORD record
ord-044d71236a4a48e8bb44a869ee2f9068
Source dataset
uspto-grants-2005_05
Patent number
US06894195B2

Reaction notes

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