Piperazine → 6'-(6-Fluoro-pyridin-2-ylmethoxy)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl

HRID 2182139Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2182139
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[N:11]=2)[N:3]=1.[NH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>>[F:16][C:12]1[N:11]=[C:10]([CH2:9][O:8][C:4]2[N:3]=[C:2]([N:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[CH:7]=[N:6][CH:5]=2)[CH:15]=[CH:14][CH:13]=1

Komponenten

3

Edukt 2

HCID 4837PiperazineHCID 224820092-Chloro-6-(6-fluoro-pyridin-2-ylmethoxy)-pyrazine

Produkt 1

HCID 99220216'-(6-Fluoro-pyridin-2-ylmethoxy)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl

Versuchsvorschrift

Following the general procedure for the preparation of I-3b above, 2-chloro-6-(6-fluoro-pyridin-2-ylmethoxy)-pyrazine (100 mg, 0.42 mmol) and piperazine (360 mg, 4.17 mmol) were reacted to give the title compound (3-B). The crude material was purified by preparative TLC using 5% methanol/methylene chloride with 1% NH4OH as the eluant to yield 23 mg of the title product (3-B).

Aufarbeitung

  1. customwere reacted

Quellen und Nachweise

ORD-Eintrag
ord-85d3a5265f5345b6a81cf4b21783202a
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06894050B2

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