Hydrochloric Acid → HCID 22481999, compound

Participants

Reaction Steps

A solution of 3′-Chloro-6′-(3-chloro-benzyloxy)-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl-4-carboxylic acid tert-butyl ester (Compound I-3g) (40 mg, 0.091 mmol) in 1,4-dioxane (0.5 ml) at 23° C. was treated with HCl in 1,4-dioxane (4 M, 0.23 ml, 0.91 mmol). The resulting mixture was stirred at room temperature for 5 h (during which a precipitate appeared) and treated with ether. The solid was collected by filtration and washed with ether to afford the title compound 3-F (27 mg, 72%).

Provenance & Evidence