HCID 69730784, compound → HCID 22482007, compound

HRID 2182144Notes

Reaction equation

HRID 2182144 reaction equation
C([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[N:18][C:17]([F:20])=[C:16]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[CH:24]=3)[N:15]=2)[CH2:10][CH2:9]1)=[O:7])(C)(C)C>C(O)=O>[CH:6]([OH:7])=[O:5].[Cl:29][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][CH:26]=1)[CH2:22][O:21][C:16]1[N:15]=[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:19]=[N:18][C:17]=1[F:20]

Participants

3

Reactant 1

HCID 69730784HCID 69730784, compound

Product 1

HCID 22482007HCID 22482007, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A solution of 6′-(3-chloro-benzyloxy)-5′-fluoro-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl-4-carboxylic acid tert-butyl ester (I-3i) (50 mg, 0.12 mmol) in formic acid (96%, 0.5 ml) was stirred at room temperature for 2 h, and concentrated in vacuo. The residue was triturated three times with ether. The title compound 3-I was collected as a white solid (15 mg, 34%). MS (ES+) Calc: 322.1, Found: 323.4 (M+1).

Workup

  1. concentrationconcentrated in vacuo
  2. customThe residue was triturated three times with ether
  3. customThe title compound 3-I was collected as a white solid (15 mg, 34%)

Sources & evidence

ORD record
ord-95fd2a6637674d669cd4729284fec043
Source dataset
uspto-grants-2005_05
Patent number
US06894050B2

Reaction notes

Loading…