Hydrochloric Acid → 5-[(3-Chlorophenyl)methoxy]-3-(1-piperazinyl)-2-pyrazinamine

Participants

Reaction Conditions

Reaction Steps

3′-Amino-6′-(3-chloro-benzyloxy)-2,3,5,6-tetrahydro-[1,2′]bipyrazinyl-4-carboxylic acid tert-butyl ester I-3s (150 mg, 357 μmol) was dissolved in 1,4-dioxane (6 mL) and an HCl solution (0.90 mL, 4 M in 1,4-dioxane, 3.6 mmol) was added with stirring at 40° C. The solution was stirred at 40° C. for 18 h and concentrated in vacuo to approximately 2 mL. The mixture was diluted with Et2O. The resulting brown solid was collected by filtration and washed twice with Et2O. The solid was purified by preparative HPLC to give the title compound 3-P as a tan solid (19 mg, 17% yield).

Provenance & Evidence