Piperazine → HCID 69732319, compound

Participants

Reaction Steps

A solution of (3-Chloro-benzyl)-(6-chloro-pyrazin-2-yl)-carbamic acid tert-butyl ester I-4e (68 mg, 0.19 mmol) and piperazine (99 mg, 1.15 mmol) in Ethanol (2 mL) were refluxed overnight. The reaction mixture was cooled and poured into 0.1M NaOH and extracted into ethyl acetate. The organic layer was washed with H2O, brine, dried (Na2SO4), and concentrated to give the title compound I-4f (38 mg).

Provenance & Evidence