Fumaric Acid → HCID 22482004, compound

Participants

Reaction Steps

A solution of (3-chloro-benzyl)-(3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl-6′-yl)-amine 4-M (1.14 g, 3.74 mmol) in a mixture of methanol (15 mL) and isopropyl Ether (90 mL) was treated with a methanolic solution of fumaric acid (434 mg in 7.5 mL Methanol, 3.74 mmol). The resulting mixture was stirred at room temperature for 1 h. Additional isopropyl Ether (120 mL) was then added to the reaction mixture and stirring continued for 10 minutes. The resulting solids were filtered from the solution and dried under high vacuum to obtain the title compound 4-N (1.25 g).

Provenance & Evidence