HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoxazole-5-carbonyl chloride → HCID 22478409, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoxazole-5-carbonyl chloride | HCID 2736707 | — |
| Reactant | 6-Amino-4-(3-chloro-4-fluoroanilino)quinazoline | HCID 10880751 | — |
| Product | HCID 22478409 | HCID 22478409 | 87% |
Reaction Steps
Using an analogous procedure to that described in Example 18, 6-amino-4-(3-chloro-4-fluoroanilino)quinazoline was reacted with 5-isoxazolecarbonyl chloride to give 4-(3-chloro-4-fluoroanilino)-6-(isoxazole-5-carboxamido)quinazoline hydrochloride salt in 87% yield, m.p.>250° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06897214B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-a2c49099c8c246ac9bc8ab2a62699f83 |
| Source note | uspto-grants-2005_05 |