HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium ethoxide → HCID 22478414, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | 6-Bromomethyl-4-(3-methylanilino)quinazoline | HCID 22478402 | — |
| Reactant | HCID 178480602 | HCID 178480602 | — |
| Reactant | HCID 178480605 | HCID 178480605 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 22478414 | HCID 22478414 | 65% |
Reaction Steps
Using an analogous procedure to that described in Example 34, 6-bromomethyl-4-(3-methylanilino)quinazoline was reacted with 2-mercapto-1-methylimidazole sodium salt [prepared by the reaction of 2-mercapto-1-methylimidazole and sodium ethoxide in ethanol] to give 4-(3-methylanilino)-6-(N-methylimidazol-2-ylthiomethyl)quinazoline in 65% yield, m.p. 137-139° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06897214B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-8e817b0a01634fab86311f9de3c98f7a |
| Source note | uspto-grants-2005_05 |