HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline dihydrochloride salt → 4-[3-Methyl-4-(2-pyridylmethoxy)anilino]-6-(2-thienyl)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline dihydrochloride salt | HCID 22478386 | — |
| Reactant | HCID 22478406 | HCID 22478406 | — |
| Product | 4-[3-Methyl-4-(2-pyridylmethoxy)anilino]-6-(2-thienyl)quinazoline | HCID 22478369 | 70% |
Reaction Steps
Using an analogous procedure to that described in Example 5, 6-bromo-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline dihydrochloride salt was reacted with di-isopropyl 2-thienylboronate to give 4-[3-methyl-4-(2-pyridylmethoxy)anilino]-6-(2-thienyl)-quinazoline in 70% yield, m.p. 205-206° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06897214B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-925bd16268f54193a3d5088554dfaa3b |
| Source note | uspto-grants-2005_05 |