tert-butyl N-(4-aminobutyl)carbamate → tert-Butyl (4-((3-nitroquinolin-4-yl)amino)butyl)carbamate

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Reaction Steps

Using the general method of Example 1 Part A, tert-butyl N-(4-aminobutyl)carbamate (254 g, 1.35 mol) was reacted with 4-chloro-3-nitroquinoline hydrochloride (331 g, 1.35 mmol) to provide 486 g of tert-butyl N-(4-[(3-nitroquinolin-4-yl)amino]butyl)carbamate as yellow solid. Analysis: Calculated for C18H24N4O4: % C, 59.99; % H, 6.71; % N, 15.55. Found: % C, 59.68; % H, 6.59; % N, 15.74.

Provenance & Evidence