1-(4-aminobutyl)-1H-imidazo[4,5-c]quinolin-4-amine → HCID 9845318, compound

Participants

Reaction Steps

According to the general method of Example 7, 1-(4-aminobutyl)-1H-imidazo[4,5-c]quinolin-4-amine and chloroformic acid 2-naphthyl ester were combined to provide 2-naphthyl N-[4-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)butyl]carbamate as a white powder, m.p. 154.0-155.0° C. 1H NMR (300 MHz, DMSO-d6) δ 8.23 (s, 1H), 8.08 (d, J=7.4 Hz, 1H), 7.94-7.86 (m, 4H), 7.64 (dd, J=8.3, 1.0 Hz, 1H), 7.56-7.43 (m, 4H), 7.30 (m, 1H), 7.20 (dd, J=8.8, 2.3 Hz, 1H), 6.61 (broad s, 2H), 4.65 (t, J=6.9 Hz, 2H), 3.14 (q, J=6.4 Hz, 2H), 1.94 (m, 2H), 1.56 (m, 2H), MS (EI) m/e 426.1927 (426.1930 calcd for C25H23N5O2).

Provenance & Evidence