4-Morpholinecarbonyl chloride → HCID 22478987, compound

Participants

Reaction Steps

Using the general method of Example 150, 1-(3-aminopropyl)-2-(3-phenoxypropyl)-1H-imidazo[4,5-c]quinolin-4-amine (2.0 g, 5.32 mmol) was reacted with 4-morpholinecarbonyl chloride (880 mg, 5.86 mmol) to provide 1.8 g of N-{3-[4-amino-2-(3-phenoxypropyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}morpholine-4-carboxamide as a light yellow crystalline solid, m.p. 198.8-199.9° C. Analysis: Calculated for C27H32N6O3: % C, 66.37; % H, 6.60; % N, 17.20. Found: % C, 66.31; % H, 6.70; % N, 17.40.

Provenance & Evidence