Phenyl isocyanate → HCID 10095117, compound

Participants

Reaction Steps

Using the general method of Example 145, 1-(3-amino-2,2-dimethylpropyl)-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine (1.0 g, 3.05 mmol) was reacted with phenyl isocyanate to provide 0.45 g of N-{3-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2,2-dimethylpropyl}-N′-phenylurea as a white powder, m.p. 125.0-130.0° C. Analysis: Calculated for C25H30N6O2.0.40 H2O: % C, 66.18; % H, 6.84; % N, 18.52. Found: % C, 66.05; % H, 6.61; % N, 18.64. % H2O calculated: 1.59. found: 1.53 (Karl Fisher);

Provenance & Evidence