4-Morpholinecarbonyl chloride → HCID 10029034, compound

Participants

Reaction Steps

Using the general method of Example 143 except that pyridine was used in place of chloroform, 1-(4-aminobutyl)-2-(3-phenoxypropyl)-1H-imidazo[4,5-c]quinolin-4-amine (1.25 g, 3.2 mmol) was reacted with 4-morpholinecarbonyl chloride (0.41 mL, 3.5 mmol) to provide 0.50 g of N-{4-[4-amino-2-(3-phenoxypropyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}morpholine-4-carboxamide as a light brown solid, m.p. 71.5-72.1° C. Analysis: Calculated for C28H34N6O3.0.5 H2O: % C, 65.73; % H, 6.90; % N, 16.43. Found: % C, 65.43; % H, 6.90; % N, 16.29.

Provenance & Evidence