HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromobenzene-1,2-diamine → 5-bromo-2-(1H-indazol-3-yl)-3H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromobenzene-1,2-diamine | HCID 323593 | — |
| Reactant | Sodium Pyrosulfite | HCID 656671 | — |
| Reactant | HCID 178520025 | HCID 178520025 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-bromo-2-(1H-indazol-3-yl)-3H-benzimidazole | HCID 135484413 | — |
Reaction Steps
Starting with 643 mg of 1H-indazole-3-carboxaldehyde, 816 mg of 4-bromo-1,2-phenylenediamine, and 836.5 mg of sodium metabisulphite in 15 ml of dimethylformamide, and after purification by SPE (SCX phase, washing with methanol, extraction with 2N ammoniacal methanol) followed by a chromatography under pressure on silica, 939 mg of 5-bromo-2-(1H-indazol-3-yl)-3H-benzimidazole are obtained in the form of a brick-red powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06897208B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-091d04c57bbf4fc782e98eef6a432610 |
| Source note | uspto-grants-2005_05 |