4-Chloro-1,2-diaminobenzene → HCID 178526863, compound

Participants

Reaction Steps

A solution of 4-chloro-benzene-1,2-diamine (500 mg) in hydrochloric acid (4N) was treated with 4-nitro-pyrazole-3-carboxylic acid (826 mg) then heated at reflux temperature, under nitrogen. The reaction mixture was cooled to room temperature when the pH was adjusted to 8 by addition of ammonium hydroxide and the mixture was extracted with ethyl acetate. The extracts were evaporated to give 5-chloro-2-(4-nitro-1H-pyrazol-3-yl)-1H-benzoimidazole. (b) 5,6-dichloro-2-(4-nitro-1H-pyrazol -3-yl)-1H-benzoimidazole

Provenance & Evidence