Diethyl Oxalate → Ethyl 2-oxo-2-(2-oxocyclohexyl)acetate

Participants

Reaction Conditions

Reaction Steps

A solution of sodium (1.75 g) in ethanol (100 ml) was treated with a mixture of diethyl oxalate (9.41 ml) and cyclohexanone (7.18 ml). The mixture was heated to 60° C. for 5 hours then cooled and then evaporated to yield oxo-(2-oxo-cyclohexyl)-acetic acid ethyl ester as a brown foam (16.635 g). LC-MS (METHOD B): RT=3.10 minutes; 197 (M−H)−. (b) 5-Methyl-2,4-dioxo-hexanoic acid ethyl ester

Provenance & Evidence