Acetic Anhydride → HCID 20785076, compound

HRID 2182405Notes

Reaction equation

HRID 2182405 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[CH:6][C:5]=1[CH2:11][CH3:12])[CH3:2].[C:13](OC(=O)C)(=[O:15])[CH3:14]>N1C=CC=CC=1.O>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:13](=[O:15])[CH3:14])=[CH:6][C:5]=1[CH2:11][CH3:12])[CH3:2]

Participants

5

Reactant 2

HCID 7918Acetic AnhydrideHCID 132598104-Ethoxy-3-ethylaniline

Product 1

HCID 20785076HCID 20785076, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1049PyridineSolvent

Procedure

To a solution of 4-ethoxy-3-ethyl-phenylamine [0.6 g, Reference Example 30(t)] in pyridine (5 mL) was added acetic anhydride (1 mL) and the mixture was stirred 18 hours at ambient temperature. The reaction mixture was diluted with water (100 mL) and the aqueous mixture was extracted twice with ethyl acetate (100 mL). The combined extracts were evaporated to give N-(4-ethoxy-3-ethyl-phenyl) acetamide (0.6 g) as a pink foam. GC-MS one peak, RT=9.16 minutes, MS 207 (M)+. (f) N-(4-Methoxy-3-methyl-phenyl)-acetamide

Workup

  1. extractionthe aqueous mixture was extracted twice with ethyl acetate (100 mL)
  2. customThe combined extracts were evaporated

Sources & evidence

ORD record
ord-d112016dafb6474391ebb6c58c0f89f3
Source dataset
uspto-grants-2005_05
Patent number
US06897208B2

Reaction notes

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