Thionyl Chloride → HCID 22480358, compound

HRID 2182510Notes

Reaction equation

HRID 2182510 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]2[O:18][C:19]([C:22]([OH:24])=O)=[CH:20][CH:21]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:27])=O>C1C=CC=CC=1>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]2[O:18][C:19]([C:22]([Cl:27])=[O:24])=[CH:20][CH:21]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 10925187HCID 10925187, compound

Product 1

HCID 22480358HCID 22480358, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

15 g (0.05 mol) of 1-benzyl-3-(5-carboxy-2-furyl)indazole and 36.43 g (0.31 mol) of thionyl chloride in 400 ml of benzene were heated under reflux for 3 h. The cooled mixture was filtered and concentrated. This gave 11.95 g (approximately 76%) of the title compound which was used for subsequent reactions without any further purification.

Workup

  1. temperatureunder reflux for 3 h
  2. filtrationThe cooled mixture was filtered
  3. concentrationconcentrated
  4. customThis gave 11.95 g (approximately 76%) of the title compound which was used for subsequent reactions without any further purification

Sources & evidence

ORD record
ord-7c7f0a1ebb714949916d712098ce2152
Source dataset
uspto-grants-2005_05
Patent number
US06897232B2

Reaction notes

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