HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2182578Generated: November 2, 2026
Divinyl sulfone → 4-(3-Hydroxypropyl)thiomorpholine 1,1-Dioxide
https://huagongshe.com/reaction/2182578
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Divinyl sulfone | HCID 6496 | — |
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Product | 4-(3-Hydroxypropyl)thiomorpholine 1,1-Dioxide | HCID 11435473 | 90% |
Reaction Steps
A mixture of 3-amino-1-propanol (650;1, 8.4 mmol) and vinyl sulphone (1 g, 8.4 mmol) was heated at 110° C. for 45 minutes. The mixture was allowed to cool and was purified by column chromatography eluting with methylene chloride/methanol (95/5) to give 3-(1,1-dioxothiomorpholino)-1-propanol (800 mg, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06897210B2 |
|---|
| Source dataset | uspto-grants-2005_05 |
|---|
| ORD ID | ord-b38ac91e6cfd469faa21af21c8e479e4 |
|---|
| Source note | uspto-grants-2005_05 |
|---|
