Triethylamine → HCID 22480521, compound

Participants

Reaction Steps

To a cooled (0° C.) solution of chloromethyl chloroformate (4.27 mmol) in EtOAc (20 ml) was slowly added a solution of 4-(2-aminophenylamino)-2-chloro-2′-methylbenzophenone (4.0 mmol) and triethylamine (4.45 mmol) in EtOAc (20 ml) under stirring. Stirring was continued at room temperature for 4 h. The reaction mixture was washed with water and 0.5 M tartaric acid, dried (Na2SO4), filtered and concentrated in vacuo. The crude product was purified by chromatography using Et2O/hexane 4:1 as eluent to give the title compound as white crystals.

Provenance & Evidence