HCID 86599410, compound → HCID 69215776, compound

Participants

Reaction Steps

To a solution of (5R,7S)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-7-azido-1,3-diazabicyclo[3.3.0]octane-2,4-dione (0.83 g) in acetic acid (20 mL) was added zinc powder (0.90 g). After 1 hour at room temperature, the mixture was concentrated. The residue was suspended in satd. NaHCO3 and EtOAc. The mixture was filtered and the organic layer was collected, washed with brine, dried (Na2SO4), filtered and concentrated. Purification of the residue by chromatography (silica gel: CH2Cl2: Chromatotron) afforded the titled compound (0.42 g). MS (m/z) 468 (MH+). mp 64.4° C.

Provenance & Evidence