Water → HCID 22479271, compound

Participants

Reaction Steps

To a solution of the compound from Example 100 (80 mg) in dry THF (2 mL) under N2 was added DIEA (0.073 mL) followed by AcCl (0.024 mL) and the reaction mixture stir-red at room temperature for 18 hours. Water (10 mL) and EtOAc (10 mL) were added and the mixture was shaken. The aqueous phase was then separated and extracted with EtOAc. The combined organics were dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by chromatography (silica gel; EtOAc/hexanes; chromatotron) to give the titled compound (71 mg). MS (m/z) 513 (MH+); mp. 91° C.

Provenance & Evidence