反应详情

11.58 g (77.2 mmol) of HOBt are weighed out in a 2-L flask. 1 L of water is added and the flask submerged in an ultrasound bath until dispersion is complete. 6.18 mL (103.1 mmol) of ethylamine are added, maintaining the ultrasonification. The dispersion is seen to dissolve completely. The transparent solution is allowed to stand for 5 minutes at room temperature. It is then frozen in a bath of dry ice and acetone. It is lyophilised. Once well lyophilised the product is withdrawn from the flask and collected in a beaker. The solid is left to dry under vacuum in the presence of KOH for at least 24 hours, to give 15.1 g of the salt of ethylamine/HOBt.

1. customthe flask submerged in an ultrasound bath until dispersion
2. temperaturemaintaining the ultrasonification
3. dissolutionto dissolve completely
4. customis withdrawn from the flask
5. customcollected in a beaker
6. waitThe solid is left
7. dry with materialto dry under vacuum in the presence of KOH for at least 24 hours