5-Quinolinamine, 2-methyl- → HCID 21948887, compound

HRID 2182644Notes

Reaction equation

HRID 2182644 reaction equation
[CH3:1][C:2]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([CH3:11])[CH2:3][C:4]1([C:7]([F:10])([F:9])[F:8])[CH2:6][O:5]1.[NH2:18][C:19]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:20]=1[CH:21]=[CH:22][C:23]([CH3:29])=[N:24]2>CCCCCC.C(OCC)(=O)C>[CH3:1][C:2]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([CH3:11])[CH2:3][C:4]([C:7]([F:10])([F:9])[F:8])([OH:5])[CH2:6][NH:18][C:19]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:20]=1[CH:21]=[CH:22][C:23]([CH3:29])=[N:24]2

Participants

4

Reactant 2

HCID 1486835-Quinolinamine, 2-methyl-HCID 21948855HCID 21948855, compound

Product 1

HCID 21948887HCID 21948887, compoundYield 58.8%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Analogously to Example 1, 500 mg (2.05 mmol) of 2-(2-methyl-2-phenylpropyl)-2-(trifluoromethyl)oxirane and 650 mg (4.10 mmol) of 5-amino-2-methylquinoline are reacted. After chromatography on silica gel with hexane-ethyl acetate (0-70%), 485 mg of product is obtained.

Sources & evidence

ORD record
ord-bd9102833522493e95955676436f2ee7
Source dataset
uspto-grants-2005_05
Patent number
US06897224B2

Reaction notes

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