反应详情

4-(5-Bromo-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid-ethyl ester in 30 ml of methanol and 12 ml of 1 M sodium hydroxide solution are stirred for 1 hour at room temperature, and the methanol is distilled off. It is mixed with water and hexane, the water phase is acidified with dilute hydrochloric acid while being cooled with ice, and it is mixed with ethyl acetate. The ethyl acetate phase is washed with water, dried (Na2SO4) and concentrated by evaporation. After crystallization from hexane, 1.8 g of 4-(5-bromo-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid is obtained. Flash point: 80° C.

1. distillationthe methanol is distilled off
2. additionIt is mixed with water and hexane
3. temperaturewhile being cooled with ice, and it
4. additionis mixed with ethyl acetate
5. washThe ethyl acetate phase is washed with water
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated by evaporation
8. customAfter crystallization from hexane