HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 5-Nitroquinolin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 2-Chloro-5-nitroquinoline | HCID 319251 | — |
| Reactant | Azane;hydrate | HCID 12896473 | — |
| Solvent | Sodium Chloride | HCID 5234 | — |
| Product | 5-Nitroquinolin-2-amine | HCID 21948914 | — |
Reaction Steps
450 mg (2.2 mmol) of 2-chloro-5-nitroquinoline, 10 ml of 25% ammonia water and 10 ml of THF are stirred in a pressure vessel for 8 hours at 120° C. The batch is diluted with NaCl solution and extracted with ethyl acetate. The combined organic phases are dried (Na2SO4) and concentrated by evaporation: 370 mg of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06897224B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-051632ff8cde4bfa8a0caf3aa8966a8b |
| Source note | uspto-grants-2005_05 |