HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 21948840, compound → HCID 21948852, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 21948840 | HCID 21948840 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | HCID 21948852 | HCID 21948852 | 60.1% |
Reaction Steps
45 mg (0.07 mmol) of 1-(6,8-dibromo-2-(methylamino)quinolin-5-ylamino)-4-(5-fluoro-2-hydroxyphenyl)-4-methyl-2-(trifluoromethyl)pentan-2-ol and 50 mg of 10% Pd—C are stirred in 2 ml for 90 minutes under hydrogen atmosphere. The batch is filtered and concentrated by evaporation. Column chromatography on silica gel with ethyl acetate-MeOH yields 19 mg of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06897224B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-3943cb333cfe4501877bb90a95ced903 |
| Source note | uspto-grants-2005_05 |